Studying the oxidative stress dynamics in conditions of wound healing during implantation of an extracellular collagen matrix 

Valeriy I. Nikol'skiy, Doctor of medical sciences, professor, professor of the sub-department of surgery, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: nvi61@yandex.ru
Artem D. Zakharov, Assistant of the sub-department of surgery, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia); surgeon of the department of purulent surgery, Clinical Hospital No. 6 named after G.A. Zakharyin (7 Stasova street, Penza, Russia), E-mail: dart_wood@mail.ru
Konstantin I. Sergatskiy, Doctor of medical sciences, associate professor of the sub-department of surgery, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia); sergeon, Penza Regional Clinical Hospital named after N. N. Burdenko (28 Lermontova street, Penza, Russia), E-mail: aleksandr_shabrov@rambler.ru
Aleksey A. Venediktov, Candidate of biological sciences, executive director of Cardioplant LLC (1V Tsentralnaya street, Penza, Russia), E-mail: info@cardioplant.ru
Yuliya A. Glumskova, Senior research engineer, head of the research laboratory, Cardioplant LLC (1V Tsentralnaya street, Penza, Russia), E-mail: info@cardioplant.ru 

Background. The issue of prevention and treatment of purulent-necrotic complications of diabetic foot syndrome is very relevant now. Despite the constant improvement of methods aimed at improving the results of treatment of purulent-necrotic complications in these patients and preventing their occurrence in general, their frequency remains at the same level. One of the factors affecting the wound process in patients with diabetes mellitus is the presence of oxidative stress in the area of the wound defect and in the perifocal zone. In conditions of diabetic angiopathy, the effectiveness of systemic pharmacotherapy is due to the impossibility of adequate delivery of drugs directly to the purulent-necrotic focus, which leads to the search for new methods of local treatment. Materials and methods. An experimental study of the effect of extracellular collagen matrix impregnated with antioxidants on the dynamics of oxidative stress in the conditions of wound process on 36 Wistar rats was carried out. An extracellular collagen matrix impregnated with ethylmethylhydroxypyridine succinate was implanted into the area of the created defect. The dynamics of the main indicators in the pro-oxidants-antioxidants system was evaluated on the 7th, 14th and 30th days after implantation. Results and conclusions. The animals of the main groups showed positive dynamics in restoring balance in the lipid peroxidation system. Thus, the use of antioxidants as part of the extracellular matrix and gel form makes it possible to neutralize the phenomena of oxidative stress in a shorter time. 

extracellular collagen matrix, antioxidants, oxidative stress, wound process, diabetes mellitus, diabetic foot syndrome 

Nikol'skiy V.I., Zakharov A.D., Shabrov A.V., Venediktov A.A., Glumskova Yu.A. Studying the oxidative stress dynamics in conditions of wound healing during implantation of an extracellular collagen matrix. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2023;(4):65–75. (In Russ.). doi: 10.21685/2072-3032-2023-4-7